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Figure 10 | Genome Biology

Figure 10

From: Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFadeletion hotspots

Figure 10

Structure and possible mechanism of formation of the homogenized AZFa-HERVs present in humans. (a) Comparison of the wild-type structure of AZFa-HERVs and the homogenized distal AZFa-HERV between ID1 and ID2 that has had 1.5 kb of L1 material removed and has been generated at least twice during recent human evolution [9]. (b) Possible two-step mechanism by which such a long portion of the distal AZFa-HERV could be homogenized via a duplicated intermediate. The constitutively haploid nature of the Y chromosome means that the substrates for the unequal crossing-over event that generates the duplicated intermediate must be sister chromatids. The unequal crossing-over event that results in deletion back to two copies might be either intra-chromosomal or between sister chromatids.

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