Figure 2

Distribution of IFN-regulated proteins at various levels of GO categories. The 1,364 proteins identified were imported into the GoMiner program to generate a directed acyclic graph (DAG) based on current annotations in the GO database. Each node of the DAG represents one GO category at various levels. (a) Fifty-four IFN-induced and (b) 24 IFN-repressed proteins were used as queries and loaded into GoMiner to classify these proteins into each GO category. The distribution of these IFN-regulated proteins is represented by a different color at each node. The color indicates a 1.5-fold enrichment (red), depletion (blue) or no change (gray) of the IFN-regulated proteins compared with the distribution over all identified proteins at that level. Several critical GO categories are labeled.