From: Molecular tumor profiling: translating genomic insights into clinical advances
Syndrome | Gene(s) responsible | Other main tumor types |
---|---|---|
Familial breast and ovarian cancer syndrome | BRCA1 and BRCA2 | Ovary, prostate and pancreas |
Li-Fraumeni syndrome | P53 | Sarcoma and brain |
Cowdens syndrome | PTEN | Thyroid and endometrial |
Mismatch repair syndrome | MLH1 and MSH2 | Gastrointestinal |
Peutz-Jegher syndrome | STK11 | Gastrointestinal |