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Table 2 Genes showing significant changes in expression throughout all biological systems tested

From: Orthologous gene-expression profiling in multi-species models: search for candidate genes

Gene symbol

Fold change

p value ventilation vs control

PubMatrix terms

   

Lung

Lung injury

Mechanical ventilation

Endothelium

Pulmonary endothelium

ALI related

       

IL-1B*

1.53

0.023

1536

287

3

1759

70

IL-6

1.84

0.015

963

173

75

527

30

F3

1.52

0.017

411

54

4

713

18

PAI-1*

1.47

0.003

201

31

3

7367

22

COX2*

1.79

0.011

257

28

1

206

9

IL-13

1.30

0.013

327

21

0

62

2

AQP-1

-1.30

0.038

49

9

0

35

6

PLAUR*

1.47

0.033

83

8

0

113

5

FGA*

1.30

0.024

22

4

10

189

12

C/EBP

1.40

0.013

27

3

0

9

2

CCL2

2.00

0.024

11

1

0

9

2

ADMR

-1.35

0.022

19

1

0

16

2

VALI candidates

       

CXCR4

1.62

0.007

26

0

0

79

4

GJA-1

1.33

0.026

7

0

0

30

1

IL1R2*

1.88

0.026

11

0

0

7

0

GADD45A

1.71

0.004

21

0

0

4

0

BTG-1*

1.38

0.007

2

0

0

1

0

TFF-2*

-1.32

0.045

9

0

0

1

0

  1. ADMR, adrenomedullin receptor; AQP-1, aquaporin 1; BTG-1, B-cell translocation gene 1; CCL2, cell chemokine 2; C/EBP, CCAAT/enhancer-binding protein; COX2, prostaglandin G/H synthase and cyclooxygenase 2; CXCR4, chemokine (C-X-C motif) receptor 4; F3, coagulation factor III (thromboplastin, tissue factor); FGA, fibrinogen alpha; GADD45A, growth arrest and DNA-damage-inducible, alpha; GJA-1, gap junction protein, alpha 1 (connexin 43); IL-1B, interleukin 1 beta; IL1R2, interleukin 1 receptor, type II; IL-6, interleukin 6; IL-13, interleukin 13; PAI-1 - plasminogen activator inhibitor type 1; PLAUR, plasminogen activator, urokinase receptor; TFF-2, trefoil factor 2 (spasmolytic protein 1). *Not detected by common single-experiment analysis.