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Table 2 Gene-expression patterns in iT3 and RTH hearts are distinct

From: Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance

 

Heart

    

Clone ID and UniGene name

iT3

RTH

Muscle related

Calcium ion binding

ATP binding and electron transport

Mitochondrion related

481408 cytochrome c oxidase, subunit VIIIa

2.78↓

NC

  

ET

MR

439199 aminolevulinic acid synthase 2, erythroid

3.33↓

NC

  

ET

MR

571367 BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3

3.89↑

1.27↓

   

MR

350881 RIKEN cDNA 5730438N18 gene

3.73↑

NC

   

MR

482847 uncoupling protein 3, mitochondrial

3.69↑

NC

   

MR

318951 malonyl-CoA decarboxylase

2.19↑

NC

   

MR

920211 solute carrier family 40 (iron-regulated transporter), member 1

2.13↑

NC

   

MR

571633 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

3.03↓

1.38↑

   

MR

318134 translocator of inner mitochondrial membrane a

3.13↓

NC

   

MR

481469 [Mrps18b]

4.00↓

NC

   

MR

423605 aldehyde dehydrogenase 1 family, member B1

3.45↓

NC

  

ATPB

MR

352146 ATP citrate lyase

2.78↓

NC

  

ATPB

 

570675 glycerol-3-phosphate dehydrogenase 1 (soluble)

3.33↓

NC

  

ATPB

 

554335 Rous sarcoma oncogene

5.00↓

NC

  

ATPB

 

1196244 lymphocyte protein tyrosine kinase

7.69↓

NC

  

ATPB

 

349954 myosin heavy chain 11, smooth muscle

2.04↓

NC

MC

 

ATPB

 

318692 sarcolipin

4.76↓

3.58↑

MC

   

604414 (vimentin)

2.56↓

2.27↑

MD

   

890932 calcium channel, voltage-dependent, alpha2/delta subunit 1

2.10↑

NC

MC

CCA

  

479382 myosin light chain, regulatory A

20.0↓

6.64↑

MC

CIB

  

354796 fibulin 1

2.38↓

NC

 

CIB

  

472672 S100 calcium binding protein A10 (calpactin)

2.70↓

NC

 

CIB

  

335868 (angiotensinogen)

3.13↓

NC

 

CIB

  
  1. ↑ indicates fold of activation; ↓ indicates fold of repression; NC indicates no changes (< 1.2-fold). MC, muscle contraction; MD, muscle development; CCA, calcium channel activity; CIB, calcium ion binding; ATPB, ATP binding; ET, electron transport; MR, mitochondrion related.