Phylogenetic tree and domain architectures of KAP NTPases. Proteins are denoted by their gene names and species abbreviations. Plasmid-borne genes are denoted by red asterisks, and phage genes are denoted by a red +; the eukaryotic branches are colored green. Species abbreviations are as in Figure 1. Filled yellow circles indicate nodes with bootstrap support of greater than 75% in the full maximum-likelihood analysis. The bootstrap values obtained through different methods (Full maximum likelihood, Rell bootstrap with Protml/Rell BP, Puzzle bootstrap/Puzzle-B, Neighbor Joining, Minimum evolution) are specifically shown for the clade that includes animal and bacterial proteins. In the schematics of protein and gene structure, conserved operons are shown as boxed arrow, and transmembrane regions inserted into the KAP domain are shown in blue. DRC0009-C and PifA-C refer to carboxy-terminal globular regions shared by the DRC0009-C and PifA subfamily KAP ATPases. Note that CPE1287 and Lmes0002 do not have the PifA-C domain.