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Table 1 Number of genes correlated with tissue metrics at three levels ofconfidence ranked by the number of significant correlations for alpha = 0.01

From: Combined histomorphometric and gene-expression profiling applied to toxicology

Rank Tissue metric Confidence level
   0.05 0.01 0.001
1 % Clear space (non-stained tissue and cellular elements) 241 74 10
2 Area % vacuoles 155 36 1
3 Vacuoles/mm2 167 28 1
4 % H&E stained elements 106 19 0
5 Area % sinusoids 74 10 0
6 Area % other nuclei 51 7 0
7 Hepatocyte nuclei/mm2 44 7 1
8 Other nuclei/mm2 46 5 0
9 Total nuclei/mm2 39 4 1
10 Area % hepatocyte nuclei 55 2 0
11 Cytoplasmic texture 19 2 0
Expected false positives 52 10 1
Number determined significant 997 194 14
  1. For details see Additional data files.