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Table 1 Features of human protein prenyltransferases

From: Protein prenyltransferases

  Farnesyltransferase (FT) Geranylgeranyltransferase I (GGT1) Geranylgeranyltransferase II (GGT2 or RabGGT)
Gene name (α subunit) FNTA FNTA RABGGTA
Gene name (β subunit) FNTB PGGT1B RABGGTB
Substrate motif Carboxy-terminal -Ca1a2X box* Carboxy-terminal -Ca1a2X box* Carboxy-terminal motif such as -CC, -CXC, -CCX, -CCXX, -CCXXX, or -CXXX
Lipid anchor Farnesyl Geranylgeranyl Geranylgeranyl(one or two moieties per substrate)
  1. *C, cysteine; a1, and a2 are amino acids that are preferably aliphatic; the identity of a1 is more flexible than a2. X can be C, S, Q, A, M, T, H, V, N, F, G, or I for FT, or L, F, I, V, or M for GGT1 (in decreasing order of affinity). Requires an escort protein such as REP1.