Skip to main content

Table 1 Features of human protein prenyltransferases

From: Protein prenyltransferases

 

Farnesyltransferase (FT)

Geranylgeranyltransferase I (GGT1)

Geranylgeranyltransferase II (GGT2 or RabGGT)

Gene name (α subunit)

FNTA

FNTA

RABGGTA

Gene name (β subunit)

FNTB

PGGT1B

RABGGTB

Substrate motif

Carboxy-terminal -Ca1a2X box*

Carboxy-terminal -Ca1a2X box*

Carboxy-terminal motif such as -CC, -CXC, -CCX, -CCXX, -CCXXX, or -CXXX†

Lipid anchor

Farnesyl

Geranylgeranyl

Geranylgeranyl(one or two moieties per substrate)

  1. *C, cysteine; a1, and a2 are amino acids that are preferably aliphatic; the identity of a1 is more flexible than a2. X can be C, S, Q, A, M, T, H, V, N, F, G, or I for FT, or L, F, I, V, or M for GGT1 (in decreasing order of affinity). †Requires an escort protein such as REP1.