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Table 1 The septin genes and proteins in five representative organisms

From: The septins

Species

Approved gene name

Chromosomal location*

Size (amino acids)

Mass (kDa)

Isoelectric point (pI)

Charge

Number of predicted coiled coils

Accession number

Saccharomyces cerevisiae

Cdc3

XII:764137

520

60.0

5.3

A

2

L16548

 

Cdc10

III:118342

322

37.0

5.6

A

0

L16549

 

Cdc11

X:576294

415

47.6

4.8

A

1

L16550

 

Cdc12

VIII:328038

407

46.7

8.2

B

1

L16551

 

Spr3

VII:607564

512

59.8

7.3

N

3

U24129

 

Spr28

IV:905043

423

48.2

5.8

A

1

NP_010504

 

Shs1/Sep7

IV:52446

551

62.6

5.3

A

2

Z74273

Schizosaccharomyces pombe

spn1

I:1067997

469

53.7

5.3

A

1

U31742

 

spn2

I:960487

331

38.1

8.0

B

0

U29888

 

spn3

II:2682372

412

46.6

4.7

A

1

U29889

 

spn4

I:1962024

380

44.7

7.0

N

1

U29890

 

spn5

I:3044705

464

53.1

8.2

B

1

U29891

 

spn6

III:421493

380

44.0

6.9

N

1

AL032824

 

spn7

II:161221

428

49.2

5.2

A

0

AF417166

Caenorhabditis elegans

unc-59

I:21.15

459

52.9

8.9

B

1

NM_060987

 

unc-61

V:6.66

530

60.7

8.9

B

1

NM_182356

Drosophila melanogaster

Pnut

44C2

539

60.2

9.0

B

1

NM_165597

 

Sep1

19F5

361

41.1

6.1

A

2

NM_167747

 

Sep2

92F2

419

48.5

7.4

N

1

NM_079693

 

Sep4

15A1

427

49.0

6.9

N

2

NM_167530

 

Sep5

43F8

422

48.5

7.3

N

1

NM_165578

Homo sapiens

Sept1

16p11.1

366

41.8

5.5

A

2

NM_052838

 

Sept2

2q37.3

361

41.5

6.2

A

2

NM_004404

 

Sept3

22q13.2

345

39.3

6.8

N

0

NM_145733

 

Sept4

17q23

478

55.1

5.7

A

2

NM_004574

 

Sept5

22q11.2

369

42.3

6.4

A

2

NM_002688

 

Sept6

Xq24

427

48.9

6.4

A

1

NM_145799

 

Sept7

7q36.1

418

48.8

9.0

B

1

NM_001788

 

Sept8

5q31

483

55.8

5.9

A

1

XM_034872

 

Sept9

17q25.3

586

65.4

9.3

B

0

AF189713

 

Sept10

8q11.23

517

60.0

6.6

N

1

BC020502

 

Sept11

4q21.22

429

49.4

6.4

A

1

NM_018243

 

Sept12

16p13.3

358

40.8

6.7

N

0

NM_144605

  1. The data refer to the largest gene products for each gene, deduced from cDNAs on the sequence databases. *The numbers given for the yeast genes refer to the position of the gene along the sequence of the chromosome. A, acidic (pI < 6.5); B, basic (pI > 7.5); N, neutral. The algorithm COILS [56, 57] was used to predict coiled coils, and the peaks above an arbitrary threshold (p > 0.8 at a window size of 14) were counted. The mouse genome has counterparts to each of the 12 human septin genes (not shown). For comparative nomenclature of the mouse and human Sept1-Sept10 genes and the products, see [58].