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Table 1 COG codes for general function and pathway/systems

From: Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level

Code

Genes

Description

General function

 

416

Information storage and processing

J

242

Translation, ribosomal structure and biogenesis

K

80

Transcription

L

94

DNA replication, recombination and repair

 

429

Metabolism

C

62

Energy production and conversion

G

71

Carbohydrate transport and metabolism

E

153

Amino acid transport and metabolism

F

50

Nucleotide transport and metabolism

H

54

Coenzyme metabolism

I

39

Lipid metabolism

 

226

Cellular processes

D

4

Cell division and chromosome partitioning

O

98

Posttranslational modification, protein turnover, chaperones

M

9

Cell envelope biogenesis, outer membrane

N

6

Cell motility and secretion

P

71

Inorganic ion transport and metabolism

T

38

Signal transduction mechanisms

 

127

Poorly characterized

R

119

General function prediction only

S

8

Function unknown

Pathway/system

-

613

No pathway/system assigned

C1

2

Pyruvate decarboxylation

C2

18

TCA cycle

C3

3

Glyoxylate bypass

E1

6

Arginine biosynthesis

E2

3

Phenylalanine/tyrosine biosynthesis

E3

3

Tryptophan biosynthesis

E4

2

Threonine biosynthesis

E5

1

Isoleucine biosynthesis

E7

19

Leucine biosynthesis

E8

7

Methionine biosynthesis

E9

4

Proline biosynthesis

E10

4

Histidine biosynthesis

F1

15

Purine biosynthesis

F2

3

Purine salvage

F3

12

Pyrimidine biosynthesis

F4

2

Pyrimidine salvage

F5

7

Thymidylate biosynthesis

G1

4

Glycolysis

G2

14

Gluconeogenesis

G3

6

Pentose phosphate pathway

G4

4

Entner-doudoroff pathway

H1

8

Heme biosynthesis

H3

2

FAD biosynthesis

H4

7

Biotin biosynthesis

H5

1

NAD biosynthesis

H6

7

Ubiquinone biosynthesis

H7

3

Menaquinone biosynthesis

H8

2

Thiamine biosynthesis

H9

1

Pyridoxal phosphate biosynthesis

I1

10

Fatty acid biosynthesis

J1

26

Translation factors and enzymes involved in translation

J2

30

Aminoacyl-tRNA synthetases, amino acid activation

J3

47

Ribosomal proteins - small subunit

J4

77

Ribosomal proteins - large subunit

K1

14

DNA-dependent RNA polymerase subunits

K2

7

Basal transcription factors

K3

2

Transcriptional regulators

L1

20

Basal replication machinery

  1. The COG letter-codes for general function and pathway/system categories are given the first column (Code). The Genes column holds the number of genes in the microarray data studied that were found for each functional class. The last column (Description) gives the description for each category.