Figure 1
Comparative genomic microarray analysis of hepatocellular carcinoma gene expression profiles. (a) A bar graph of log-transformed expression ratios (tumor versus normal) for genes located on chromosome 8q for sample SF13. The gene-expression values are organized from the chromosome telomere (top) to the centromere (bottom). A scale is shown above the graph. (b) CGMA expression profiles for 104 HCC tissue samples. Before CGMA analysis, gene-expression ratios were transformed such that each tumor gene-expression value was compared to the expression value from the non-cancerous tissue sample retrieved from the same patient. If the normal tissue was not present, the global mean of the non-tumor tissues was used. Genomic regions that show a significant number of downregulated genes are shown in green whereas genomic regions that show a significant number of upregulated genes are shown in red. The color intensity indicates the significance of the expression bias. The lowest-intensity color indicates a z-statistic = 1.96 (α = 0.05) while the most intense color indicates a z-statistic <3.29 (α < 0.001). The mean z-statistic for each genomic region is displayed in the rightmost column. (c) Chromosomal regions that had a significant gene-expression bias in more than 35% of HCC samples are listed. Red represents chromosomal gains and green represents losses. The corresponding percentages of samples that displayed frequent chromosomal aberrations identified in two CGH studies. Values from Wong et al.[12] are represented as CGH1 and values from Marchio et al. [11] are represented as CGH2.