Z-scores for component proteins. The graph illustrates the Z-score (blue bars) distribution and its cumulative sum (step function, with red rectangles) between components, for all detected fusion events (66,406 in total). The Z-score is a statistical measure of similarity for each pair of components. Components that have a Z-score similarity of less than 10, and both exhibit similarity to the same composite protein are detected as fusion events. In general, fusion events where the Z-score between components is less than 3 (marked by a vertical line) result in fewer false-positive fusion detections.