Figure 2

Structures of the vertebrate dystrophin/dystrobrevin family compiled from the crystal structures of the dystrophin actin-binding domain, two spectrin repeats from α-actinin, and the cysteine-rich region of dystrophin (PDB numbers 1dxx, 1quu and 1eg4, respectively). Actin binding region: cyan, CH1; green, CH2. 'Cysteine-rich' region: green, WW domain; red, orange, cyan, and purple, EF hands. Carboxy-terminal region: yellow, syntrophin-binding segment; red, leucine heptads.