A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

Table 5 Violations of Chargaff's rule and rate constancy

|slope AB| is the absolute value of the change of a given nucleotide at a given position (relative to total coding sequence GC content) in archaea/bacteria; |slope E| is the corresponding slope in eukaryotes. Error is a measure of the average consequence of a change in a particular base at a particular codon position (for example, T1 is T at the first position, using a methodology based on [69]. See text for explanation.

ISSN: 1474-760X