Gene | Survival of null mutant* | Phenotype | References |
---|---|---|---|
Fgf1 | Viable | None identified | [110] |
Fgf2 | Viable | Mild cardiovascular, skeletal, neuronal | [110,111,112,113,114] |
Fgf3 | Viable | Mild inner ear, skeletal (tail) | [115] |
Fgf4 | Lethal, E4-5 | Inner cell mass proliferation | [116] |
Fgf5 | Viable | Long hair, angora mutation | [72] |
Fgf6 | Viable | Subtle, muscle regeneration | [117,118,119] |
Fgf7 | Viable | Hair follicle growth, ureteric bud growth | [120,121] |
Fgf8 | Lethal, E7 | Gastrulation defect, CNS development, limb development | [67,70,122,123] |
Fgf9 | Lethal, P0 | Lung mesenchyme, XY sex reversal | [124]; (J.S. Colvin et al., personal communication) |
Fgf10 | Lethal, P0 | Development of multiple organs, including limb, lung, thymus, pituitary | [125,126,127] |
Fgf12 (Fhf1) | Viable | Neuromuscular phenotype | (J. Schoorlemmer and M. Goldfarb, personal communication) |
Fgf14 (Fhf4) | Viable | Neurological phenotypes | (Q. Wang, personal communication) |
Fgf15 | Lethal, E9.5 | Not clear | (J.R. McWhirter, personal communication) |
Fgf17 | Viable | Cerebellar development | [17] |
Fgf18 | Lethal, P0 | Skeletal development | (N. Ohbayashi, Z. Liu, personal communication) |