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Figure 5 | Genome Biology

Figure 5

From: Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls

Figure 5

Reproducibility of normalization methods for different degrees of spike-skew in simulated data. The SD of the random multiplicative spike-skew term in the simulations was adjusted from 0.1 to 0.4 (10-40%). Increasing spike-skew specifically degrades the performance of the F metric. Note that the relatively poor performance of F relative to Fs and ADs when the spike-skew is 0.2 (20%) is similar to that observed in the experimental data (Figure 3). Twenty simulated hybridizations were generated for each level of spike-skew.

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