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Figure 4 | Genome Biology

Figure 4

From: Quod erat demonstrandum?The mystery of experimental validation of apparently erroneous computational analyses of protein sequences

Figure 4

Multiple alignment of predicted archaeal thymidylate synthases (TS). The scheme for displaying multiple alignments is as described in the legend to Figure 1. Residues are colored at 90% consensus. A consensus secondary structure was derived using known TS structures from R. norvegicus, E. coli and bacteriophage T4 deoxycytidylate hydroxymethyltransferase (1B5D). The Archaeoglobus fulgidus TS has a duplication of the TS domain and the amino-terminal domain (N.TS_Af; shaded gray) is predicted to be inactive. Af, Archaeoglobus fulgidus; At, Arabidopsis thaliana; BPSP1; bacteriophage SP1; Bs, B. subtilis; Dm, Drosophila melanogaster; Dr, D. radiodurans; Ec, E. coli; Mj, M. jannaschii; Mt, M. tuberculosis; Mth, M. thermoautotrophicum; Nm, Neisseria meningitidis; Rn, R. norvegicus; T2, bacteriophage T2; Xf, Xylella fastidiosa.

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