- Web report
- Open Access
Ribozymes as tools for the analysis of gene function
- Ines Chyla
© BioMed Central Ltd 2000
- Received: 20 October 1999
- Published: 17 March 2000
Valuable information on the use of ribozymes as tools for the analysis of gene function can be found here.
- Gene Function
- Comprehensive Information
- Cellular Gene
- Cellular Factor
- Important Paper
Valuable information on the use of ribozymes as tools for the analysis of gene function can be found here. How ribozymes function to perturb gene expression is discussed in detail. A review article focuses on the use of ribozymes as specific inhibitors of viral and cellular gene expression, both in tissue culture cells and at the level of the whole organism. The review covers the role of cellular factors, such as RNA-binding proteins, as possible facilitators of ribozyme action within cells. A computational approach to identifying possible target sites for ribozyme action is also described.
The site was last updated 30 April 1997.
This is the best comprehensive information on ribozymes available on-line, and is supported by explanatory graphics.
Apart from the lack of updates, there is no real site structure and many links are broken. Some of the graphics are too large to be printed without becoming truncated.
The site needs a thorough update to repair the broken links, especially the external ones. It would also benefit from the addition of links to other important papers on the subject, and a general update to include recent developments.