Fig. 2
From: spVC for the detection and interpretation of spatial gene expression variation
Overview of the spVC method. A The required input of spVC includes the spatial transcriptomics data (the read count matrix and the corresponding spatial location matrix) and the spot-level covariate data. The covariates should be provided for the same spots observed in the spatial transcriptomics data. B The four main steps in spVC’s estimation procedure. C The two-step testing procedure used in this article. D For each gene, spVC outputs the estimated constant and spatial effects as well as their corresponding P values