Fig. 1
From: spVC for the detection and interpretation of spatial gene expression variation
Spatial variation of gene expression introduced by different factors. A Three hypothetical genes with observed spatial variation introduced by different underlying factors. “Constant effect” and “Spatially varying effect” refer to constant and spatially varying coefficients of the covariate, respectively. “Residual spatial effect” refers to spatial effects independent of the covariate. A “\(\checkmark\)” means that the effect is present. B Spot-level cell type proportions. C Read counts generated from Poisson distributions, whose mean parameters are based on the scenarios specified in A. For simplicity, we assume no difference in library size across spots. D Spatially varying effects of the cell type proportion in scenario 2. The average effect is 0 in this square domain so it remains identifiable. E Residual spatial effects in scenario 3. The average effect is 0 in this square domain so it remains identifiable from the constant effect of cell type proportion