Fig. 4
From: Measuring, visualizing, and diagnosing reference bias with biastools
Bias-by-allele-length for 8 alignment workflows. We used simulated and real WGS datasets derived from HG002. We subsetted to reads aligning to HET sites on chromosome 20. Variants are arranged according to their length, with positive values standing for insertions and negative values standing for deletions. Zero indicates SNVs. a Fraction of ALT alleles in the simulation (blue) and after mapping of simulated reads (other colors). b Fraction of ALT alleles after mapping and context-aware assignment using simulated reads. c Fraction of ALT alleles after mapping and context-aware assignment using real reads. d The number of incidents of each size